2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

Base Information

Chemical Name:2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile
CAS No.:1403598-31-1
Molecular Formula:C₁₈H₁₇BrFN₃O
Molecular Weight:390.255
Hs Code.:

Synonyms:2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

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Chemical Property of 2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

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Technology Process of 2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

There total 5 articles about 2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1152617-14-5
2,4-dibromopyridine-3-carbonitrile

: 1403598-30-0
4-(3-fluoro-2-methoxyphenyl)piperidine hydrochloride

: 1403598-31-1
2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1.08333h;
DOI:10.1021/jm300912k

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1403598-31-1
2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

3: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.08 h / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; potassium carbonate; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm300912k

Reference yield:

: 1403598-29-7
tert-butyl 4-(3-fluoro-2-methoxyphenyl)-3,6-dihydropyridine-1(2H)-carboxylate

: 1403598-31-1
2-bromo-4-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C

2: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.08 h / 0 - 20 °C

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; In methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm300912k