benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester

Base Information

• Chemical Name: benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester
• CAS No.: 945934-00-9
• Molecular Formula: C₁₅H₂₄NO₅P
• Molecular Weight: 329.333
• Mol file: 945934-00-9.mol

Synonyms:benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester

Chemical Property of benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester

There total 2 articles about benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) + benzylphosphonic acid monomethyl ester (63581-66-8) → benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester (945934-00-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2007.04.026

Reference yield:

dimethyl benzylphosphonate (773-47-7) → benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester (945934-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / LiHBEt₃ / tetrahydrofuran / 20 °C

2: 94 percent / DEAD; triphenyl phosphine / tetrahydrofuran / 20 °C

With lithium triethylborohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2007.04.026

Reference yield: 74.0%

benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl methyl ester (945934-00-9) → benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl ester (945934-02-1)

Guidance literature:

With L-Selectride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.04.026

upstream raw materials:

2-(N-tert-butoxycarbonylamino)ethanol

benzylphosphonic acid monomethyl ester

dimethyl benzylphosphonate

Downstream raw materials:

benzylphosphonic acid 2-(tert-butoxycarboxamido)ethyl ester