N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester

Base Information

• Chemical Name: N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester
• CAS No.: 256477-32-4
• Molecular Formula: C₂₂H₂₈Cl₂N₂O₄S
• Molecular Weight: 487.447
• Mol file: 256477-32-4.mol

Synonyms:N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester

Chemical Property of N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester

There total 5 articles about N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]glycine tert-butyl ester (256477-27-7) + pentane-EtOAc + Cyclohexylmethyl bromide (2550-36-9) → N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester (256477-32-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

1-isoquinolone (491-30-5) → N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester (256477-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-chloro-succinimide / acetonitrile

2: triethylamine / dichloromethane

3: potassium carbonate / N,N-dimethyl-formamide

With N-chloro-succinimide; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride (223671-81-6) → N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester (256477-32-4)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / diethyl ether; acetonitrile

2: triethylamine / dichloromethane

3: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; triethylamine; trichlorophosphate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]glycine tert-butyl ester

Cyclohexylmethyl bromide

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

1,4-dichloro-7-isoquinolinesulphonyl chloride

Downstream raw materials:

N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester