N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester

Base Information

Chemical Name:N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester
CAS No.:256478-24-7
Molecular Formula:C₂₃H₃₂ClN₅O₄S
Molecular Weight:510.057
Hs Code.:

Synonyms:N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester

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Chemical Property of N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester

Chemical Property:

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Technology Process of N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester

There total 9 articles about N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256477-32-4
N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester

: pentane-EtOAc

: 50-01-1
guanidine hydrochloride

: 256478-24-7
N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester

: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine hydrochloride

Guidance literature:: With NaH; In 1,2-dimethoxyethane; ethyl acetate; mineral oil;

Reference yield:

: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine hydrochloride

: 256477-32-4
N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester

: pentane-EtOAc

: 50-01-1
guanidine hydrochloride

: 256478-24-7
N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester

Guidance literature:: With NaH; In 1,2-dimethoxyethane; ethyl acetate; mineral oil;

Reference yield:

: 491-30-5
1-isoquinolone

: 256478-24-7
N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester

: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide / acetonitrile

2: triethylamine / dichloromethane

3: potassium carbonate / N,N-dimethyl-formamide

4: NaH / 1,2-dimethoxyethane; ethyl acetate; mineral oil

With N-chloro-succinimide; NaH; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;