N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide

Base Information

• Chemical Name: N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide
• CAS No.: 831196-82-8
• Molecular Formula: C₂₅H₂₇NO₅
• Molecular Weight: 421.493
• Mol file: 831196-82-8.mol

Synonyms:N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide

Chemical Property of N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide

There total 6 articles about N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethoxyphenylacetyl chloride (10313-60-7) + (R)-(-)-2-amino-1-(p-benzyloxyphenyl)ethanol (473552-26-0) → N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide (831196-82-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tetasy.2004.11.013

Reference yield:

p-benzyloxy-ω-azidoacetophenone (831196-83-9) → N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide (831196-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride; activated neutral alumina / diisopropyl ether / 40 °C

With aluminum oxide; sodium tetrahydroborate; In di-isopropyl ether;

DOI:10.1016/j.tetasy.2004.11.013

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → N-[2-(4-benzyloxy-phenyl)-2-hydroxy-ethyl]-2-(3,4-dimethoxy-phenyl)-acetamide (831196-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyvaloyl chloride; triethylamine / tetrahydrofuran / -78 °C

2: 0.985 g / triethylamine / tetrahydrofuran / -78 - 20 °C

With pivaloyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.tetasy.2004.11.013

upstream raw materials:

3,4-dimethoxyphenylacetyl chloride

(R)-(-)-2-amino-1-(p-benzyloxyphenyl)ethanol

(3,4-Dimethoxyphenyl)acetic acid

p-benzyloxy-ω-azidoacetophenone

Downstream raw materials:

(R)-1-(p-benzyloxyphenyl)-2-[2-(3,4-dimethoxyphenyl)ethylamino]ethanol

denopamine