Denopamine

Base Information

Chemical Name:Denopamine
CAS No.:71771-90-9
Molecular Formula:C18H23 N O4
Molecular Weight:317.385
Hs Code.:
European Community (EC) Number:635-334-1
UNII:V5F60UPD8P
DSSTox Substance ID:DTXSID8045800
Nikkaji Number:J23.679I
Wikipedia:Denopamine
Wikidata:Q5259281
NCI Thesaurus Code:C77934
Pharos Ligand ID:GNKYA5LNN912
ChEMBL ID:CHEMBL493682
Mol file:71771-90-9.mol

Synonyms:(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol;1-(p-hydroxyphenyl)-2-((3,4-dimethoxyphenethyl)amino)ethanol;denopamine;TA 064;TA-064

Suppliers and Price of Denopamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(-)-Denopamine
5mg
$ 760.00

Sigma-Aldrich
R(?)-Denopamine ≥98% (HPLC), powder
5mg
$ 240.00

Medical Isotopes, Inc.
(R)-(-)-Denopamine
5 mg
$ 490.00

AK Scientific
R(-)-Denopamine
5mg
$ 349.00

AHH
R(-)-Denopamine 98%
0.025g
$ 350.00

Total 27 raw suppliers

Chemical Property of Denopamine

Chemical Property:

Vapor Pressure:1.37E-11mmHg at 25°C
Melting Point:135°C
Refractive Index:1.5740 (estimate)
Boiling Point:518.8°C at 760 mmHg
Flash Point:267.6°C
PSA：70.95000
Density:1.177g/cm³
LogP:2.66600
Storage Temp.:2-8°C
Solubility.:DMSO: 26 mg/mL, soluble
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:317.16270821
Heavy Atom Count:23
Complexity:320

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(-)-Denopamine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 62-63
Safety Statements: 22-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCNCC(C2=CC=C(C=C2)O)O)OC
Isomeric SMILES:COC1=C(C=C(C=C1)CCNC[C@@H](C2=CC=C(C=C2)O)O)OC
Description Denopamine is a potent orally-active cardiotonic with selective effects on the beta, adrenergic receptors. Unlike isoproterenol or dobutamine, denopamine’s positive inotropic activity is not mediated through the release of catecholamines; its lack of effect on heart rate and myocardial oxygen consumption thus offers significant advantages in the management of congestive heart failure.
Uses R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).

Technology Process of Denopamine

There total 38 articles about Denopamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 2-[2-(3,4-dimethoxy-phenyl)-ethylamino]-1-(4-hydroxy-phenyl)-ethanone hydrochloride

: 71771-90-9
denopamine

Guidance literature:: With hydrogen; sodium t-butanolate; In isopropyl alcohol; at 20 ℃; for 16h; Inert atmosphere; Autoclave;

Reference yield: 96.0%

: 63365-60-6
(R)-1-(p-benzyloxyphenyl)-2-[2-(3,4-dimethoxyphenyl)ethylamino]ethanol

: 71771-90-9
denopamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 6h; under 760 Torr;
DOI:10.1016/j.tetasy.2004.11.013