(R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

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Chemical Name:(R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol
CAS No.:209065-36-1
Molecular Formula:C₄₀H₅₅NO₆Si
Molecular Weight:673.965
Hs Code.:

(R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

Synonyms:(R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

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Chemical Property of (R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

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Technology Process of (R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

There total 28 articles about (R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: (R)-4-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 209065-36-1
(R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: With acetyl chloride; In methanol; at 20 - 25 ℃; for 4h;
DOI:10.1021/ja108906e

Reference yield:

: 193416-31-8
(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

: 209065-36-1
(R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/ja980621g

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 209065-36-1
(R)-2-Amino-2-((2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-ethanol

Guidance literature:: Multi-step reaction with 14 steps

1: triethylamine / N,N-dimethyl-formamide / 20 - 25 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 20 - 25 °C

3: phosgene; dimethyl sulfoxide; triethylamine / dichloromethane / 20 - 25 °C

4: chromium dichloride; nickel dichloride / tetrahydrofuran / 20 - 25 °C

5: triphenylphosphine; diethylazodicarboxylate / 20 - 25 °C

6: potassium carbonate / methanol / 20 - 25 °C

7: triethylamine / dichloromethane / 0 °C

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

9: triethylamine / acetonitrile / Reflux

10: toluene-4-sulfonic acid / methanol / 20 - 25 °C

11: 1H-imidazole / 20 - 25 °C

12: diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 - 25 °C

13: water; triphenylphosphine / Reflux

14: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 - 25 °C

With 1H-imidazole; chromium dichloride; phosgene; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; water; potassium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 4: Nozaki-Hiyama-Kishi coupling / 5: Mitsunobu inversion;
DOI:10.1021/ja108906e