(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

Base Information

Chemical Name:(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine
CAS No.:193416-31-8
Molecular Formula:C₄₆H₆₉NO₆Si₂
Molecular Weight:788.228
Hs Code.:

(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

Synonyms:(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

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Chemical Property of (R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

Chemical Property:

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Technology Process of (R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

There total 16 articles about (R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 193416-31-8
(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

Guidance literature:: Multi-step reaction with 11 steps

1: 93 percent / Et₃N

2: 97 percent / DDQ / CH₂Cl₂

3: 80 percent

4: CrCl₂/NiCl₂ / tetrahydrofuran

5: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

6: 96 percent / Et₃N / CH₂Cl₂

7: 94 percent / TBAF

8: 86 percent / Et₃N / acetonitrile / Heating

9: 97 percent / TsOH / methanol

10: 83 percent / imidazole

11: Ph₃P, H₂O / tetrahydrofuran

With 1H-imidazole; chromium dichloride; tetrabutyl ammonium fluoride; water; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo9708755

Reference yield:

: {2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-[2-(4-methoxy-benzyloxy)-ethyl]-3,6-dihydro-2H-pyran-4-yloxy}-triethyl-silane

: 193416-31-8
(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

Guidance literature:: Multi-step reaction with 13 steps

1: TBAF, TsOH / tetrahydrofuran

2: 97 percent / K(s-Bu₃BH) / tetrahydrofuran

3: 93 percent / Et₃N

4: 97 percent / DDQ / CH₂Cl₂

5: 80 percent

6: CrCl₂/NiCl₂ / tetrahydrofuran

7: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

8: 96 percent / Et₃N / CH₂Cl₂

9: 94 percent / TBAF

10: 86 percent / Et₃N / acetonitrile / Heating

11: 97 percent / TsOH / methanol

12: 83 percent / imidazole

13: Ph₃P, H₂O / tetrahydrofuran

With 1H-imidazole; chromium dichloride; tetrabutyl ammonium fluoride; water; potassium tri-sec-butyl-borohydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo9708755

Reference yield:

: 193416-38-5
(2R,6R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-[2-(4-methoxy-benzyloxy)-ethyl]-tetrahydro-pyran-4-one

: 193416-31-8
(R)-1-((2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(2R,6R)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-tetrahydro-pyran-2-yl)-2-triethylsilanyloxy-ethylamine

Guidance literature:: Multi-step reaction with 12 steps

1: 97 percent / K(s-Bu₃BH) / tetrahydrofuran

2: 93 percent / Et₃N

3: 97 percent / DDQ / CH₂Cl₂

4: 80 percent

5: CrCl₂/NiCl₂ / tetrahydrofuran

6: 1.) PNBA, Ph₃P, DEAD, 2.) K₃CO₃ / 2.) MeOH

7: 96 percent / Et₃N / CH₂Cl₂

8: 94 percent / TBAF

9: 86 percent / Et₃N / acetonitrile / Heating

10: 97 percent / TsOH / methanol

11: 83 percent / imidazole

12: Ph₃P, H₂O / tetrahydrofuran

With 1H-imidazole; chromium dichloride; tetrabutyl ammonium fluoride; water; potassium tri-sec-butyl-borohydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo9708755