(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

Base Information

Chemical Name:(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane
CAS No.:1235570-42-9
Molecular Formula:C₂₄H₃₄O₄Si
Molecular Weight:414.617
Hs Code.:

Synonyms:(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

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Technology Process of (2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

There total 3 articles about (2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 102778-93-8,92512-38-4
(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-pentane-1,2,4-triol

: 3188-13-4
ethyl chloromethyl ether

: 1235570-42-9
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

Guidance literature:: (2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-pentane-1,2,4-triol; With potassium hexamethylsilazane; 1-[(2,4,6-triisopropylphenyl)sulfonyl]-1H-imidazole; In tetrahydrofuran; at 0 ℃;

ethyl chloromethyl ether; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1039/c0cc00056f

Reference yield:

: 92512-41-9
C₂₁H₂₈O₃Si

: 3188-13-4
ethyl chloromethyl ether

: 1235570-42-9
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/jo201729t

Reference yield:

: 102778-93-8,92512-38-4
(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-pentane-1,2,4-triol

: 1235570-42-9
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / toluene / 0.08 h / 20 °C

1.2: 1 h / 20 °C

2.1: triethylamine / dichloromethane / 48 h / 20 °C

With potassium hexamethylsilazane; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jo201729t