(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

Base Information

Chemical Name:(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol
CAS No.:1235570-48-5
Molecular Formula:C₂₈H₄₂O₄S₂Si
Molecular Weight:534.857
Hs Code.:

Synonyms:(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

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Chemical Property of (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

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Technology Process of (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

There total 3 articles about (2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 505-23-7
1,3 dithiane

: 1235570-42-9
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane

: 1235570-48-5
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

Guidance literature:: 1,3 dithiane; With n-butyllithium; In tetrahydrofuran; at -20 ℃;

(2S,4S)-1-(tert-butyldiphenylsilyloxy)-2-(ethoxymethoxy)-4,5-epoxypentane; In tetrahydrofuran; at 0 ℃;
DOI:10.1039/c0cc00056f

Reference yield:

: 92512-41-9
C₂₁H₂₈O₃Si

: 1235570-48-5
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 48 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo201729t

Reference yield:

: 102778-93-8,92512-38-4
(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-pentane-1,2,4-triol

: 1235570-48-5
(2S,4S)-1-(tert-butyldiphenylsilyloxy)-5-(1,3-dithian-2-yl)-2-(ethoxymethoxy)-4-pentanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / toluene / 0.08 h / 20 °C

1.2: 1 h / 20 °C

2.1: triethylamine / dichloromethane / 48 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

With n-butyllithium; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/jo201729t