benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate

Base Information

Chemical Name:benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate
CAS No.:868066-56-2
Molecular Formula:C₂₃H₂₉N₃O₃
Molecular Weight:395.502
Hs Code.:

Synonyms:benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate

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Chemical Property of benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate

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Technology Process of benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate

There total 1 articles about benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 19715-80-1
2-(4-bromophenyl)-N,N-dimethyl acetamide

: 117009-97-9
benzyl 1,4-diazepane-1-carboxylate

: 868066-56-2
benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; DavePhos; In 1,4-dioxane; tert-butyl alcohol; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2013.01.071

Reference yield: 94.0%

: 868066-56-2
benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate

: 868066-58-4
2-[4-(1,4-diazepan-1-yl)phenyl]-N,N-dimethylacetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2013.01.071

Reference yield:

: 868066-56-2
benzyl 4-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}-1,4-diazepane-1-carboxylate

: 868066-54-0
3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / 20 °C

2: N,N-dimethyl-formamide / 0.5 h / 20 °C

3: N,N-dimethyl-formamide / 1.5 h / 20 - 60 °C

4: sodium hydroxide / water; N,N-dimethyl-formamide / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.071