3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

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Chemical Name:3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide
CAS No.:868066-54-0
Molecular Formula:C₂₃H₂₈N₆O₂S
Molecular Weight:452.58
Hs Code.:

Synonyms:3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

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Chemical Property of 3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

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Technology Process of 3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

There total 9 articles about 3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 868066-60-8
2-{4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]phenyl}-N,N-dimethylacetamide

: 79-07-2
Chloroacetamide

: 868066-54-0
3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: With sodium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2013.01.071

Reference yield: 45.0%

: methyl 3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxylate

: 868066-54-0
3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: methyl 3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 60 ℃;

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With ammonium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 19715-80-1
2-(4-bromophenyl)-N,N-dimethyl acetamide

: 868066-54-0
3-amino-4-(4-(4-(2-(dimethylamino)-2-oxoethyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; DavePhos / tert-butyl alcohol; 1,4-dioxane / 2 h / Inert atmosphere; Reflux

2: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / 20 °C

3: N,N-dimethyl-formamide / 0.5 h / 20 °C

4: N,N-dimethyl-formamide / 1.5 h / 20 - 60 °C

5: sodium hydroxide / water; N,N-dimethyl-formamide / 1 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium hydroxide; sodium t-butanolate; DavePhos; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2013.01.071