4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

Base Information

Chemical Name:4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile
CAS No.:161196-56-1
Molecular Formula:C₃₅H₄₈ClN₃OS₃Si
Molecular Weight:686.522
Hs Code.:

4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

Synonyms:4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

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Chemical Property of 4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

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Technology Process of 4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

There total 8 articles about 4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 39141-31-6
2-lithio-2-(methylthio)-1,3-dithiane

: 4'-{1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-iodo-propyl}-biphenyl-2-carbonitrile

: 161196-56-1
4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(00)78550-9

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 161196-56-1
4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 67 percent / hexamethylenetetramine / acetic acid; H₂O / 1 h / 120 °C

2: 1.) NaH; 2.) NaH, I₂ / 1.) DME, 0 degC; 2.) 25-40 degC

3: Li₂CO₃ / dimethylformamide / 16 h / 80 °C

4: NaBH₄ / methanol / 1 h / -10 °C

5: NaHTe / ethanol / 3 h / Ambient temperature

6: 1.) Im; 2.) NaBH₄, CaCl₂ / 1.) DMF, room t., 3 h; 2.) i-PrOH, room t., 22 h

7: 92 percent / I₂, PPh₃, Py / tetrahydrofuran / 48 h / Ambient temperature

8: 92 percent / tetrahydrofuran / 1 h / -78 °C

With pyridine; sodium tetrahydroborate; sodium hydrogen telluride; hexamethylenetetramine; impramine; iodine; lithium carbonate; sodium hydride; triphenylphosphine; calcium chloride; In tetrahydrofuran; methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)78550-9

Reference yield:

: 135689-93-9
4-(2-Cyanophenyl)benzaldehyde

: 161196-56-1
4'-[1-[2-Butyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-imidazol-1-yl]-3-(2-methylsulfanyl-[1,3]dithian-2-yl)-propyl]-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH; 2.) NaH, I₂ / 1.) DME, 0 degC; 2.) 25-40 degC

2: Li₂CO₃ / dimethylformamide / 16 h / 80 °C

3: NaBH₄ / methanol / 1 h / -10 °C

4: NaHTe / ethanol / 3 h / Ambient temperature

5: 1.) Im; 2.) NaBH₄, CaCl₂ / 1.) DMF, room t., 3 h; 2.) i-PrOH, room t., 22 h

6: 92 percent / I₂, PPh₃, Py / tetrahydrofuran / 48 h / Ambient temperature

7: 92 percent / tetrahydrofuran / 1 h / -78 °C

With pyridine; sodium tetrahydroborate; sodium hydrogen telluride; impramine; iodine; lithium carbonate; sodium hydride; triphenylphosphine; calcium chloride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)78550-9