N-(5,5-diacetoxypentyl)doxorubicin

Base Information

Chemical Name:N-(5,5-diacetoxypentyl)doxorubicin
CAS No.:138967-27-8
Molecular Formula:C₃₆H₄₃NO₁₅
Molecular Weight:729.735
Hs Code.:
Mol file:138967-27-8.mol

Synonyms:5,12-Naphthacenedione,10-[[3-[[5,5-bis(acetyloxy)pentyl]amino]-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S-cis)-

Suppliers and Price of N-(5,5-diacetoxypentyl)doxorubicin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of N-(5,5-diacetoxypentyl)doxorubicin

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:929°Cat760mmHg
Flash Point:515.7°C
PSA：244.68000
Density:1.48g/cm³
LogP:1.64570

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(5,5-diacetoxypentyl)doxorubicin

There total 4 articles about N-(5,5-diacetoxypentyl)doxorubicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 25316-40-9
doxorubicin hydrochloride

: 142564-05-4
Acetic acid 1-acetoxy-5-oxo-pentyl ester

: 138967-27-8
N-(5,5-diacetoxypentyl)doxorubicin

Guidance literature:: With sodium cyanoborohydride; In tetrahydrofuran; water; acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jm00095a017

Reference yield:

: 821-41-0
5-Hexen-1-ol

: 138967-27-8
N-(5,5-diacetoxypentyl)doxorubicin

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / N-methylmorpholine N-oxide, tetrapropylammonium perruthenate, 4 Angstroem sieves / CH₂Cl₂ / 2 h / Ambient temperature

2: 94 percent / BF₃*Et₂O / diethyl ether / 0.17 h / Ambient temperature

3: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -70 deg C, 20 min, 2.) CH₂Cl₂, overnight

4: NaBH₃CN / acetonitrile; H₂O; tetrahydrofuran / 1 h / Ambient temperature

With tetrapropylammonium perruthennate; dimethylsulfide; 4 A molecular sieve; boron trifluoride diethyl etherate; sodium cyanoborohydride; ozone; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jm9706980

Reference yield:

: 764-59-0
hex-5-en-1-al

: 138967-27-8
N-(5,5-diacetoxypentyl)doxorubicin

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / BF₃*Et₂O / diethyl ether / 0.17 h / Ambient temperature

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -70 deg C, 20 min, 2.) CH₂Cl₂, overnight

3: NaBH₃CN / acetonitrile; H₂O; tetrahydrofuran / 1 h / Ambient temperature

With dimethylsulfide; boron trifluoride diethyl etherate; sodium cyanoborohydride; ozone; In tetrahydrofuran; diethyl ether; water; acetonitrile;
DOI:10.1021/jm9706980