3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester

Base Information

• Chemical Name: 3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester
• CAS No.: 185448-82-2
• Molecular Formula: C₃₃H₃₃NO₅
• Molecular Weight: 523.629

Synonyms:3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester

Chemical Property of 3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester

There total 7 articles about 3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-oxo-ethyl]-amino}-propionic acid ethyl ester (185448-76-4) → 3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester (185448-82-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 1h; Ambient temperature;

DOI:10.1016/S0223-5234(97)89848-0

Reference yield:

Ethyl 3-bromopropionate (539-74-2) → 3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester (185448-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / tetrahydrofuran

2: 85.5 percent / Et₃N, sodium iodide / dimethylformamide / 3 h / 0 °C

3: 79 percent / NaBH₄ / ethanol / 1 h / Ambient temperature

With sodium tetrahydroborate; triethylamine; sodium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(97)89848-0

Reference yield:

Dichlorodiphenylmethane (2051-90-3) → 3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-hydroxy-ethyl]-amino}-propionic acid ethyl ester (185448-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / 0.25 h / 170 - 180 °C

2: 85.5 percent / Et₃N, sodium iodide / dimethylformamide / 3 h / 0 °C

3: 79 percent / NaBH₄ / ethanol / 1 h / Ambient temperature

With sodium tetrahydroborate; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(97)89848-0

upstream raw materials:

3-{Benzyl-[2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-2-oxo-ethyl]-amino}-propionic acid ethyl ester

Ethyl 3-bromopropionate

Dichlorodiphenylmethane

2-chloro-3',4'-dihydroxyacetophenone

Downstream raw materials:

3-[2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylamino]-propionic acid ethyl ester

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