methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

Base Information

Chemical Name:methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate
CAS No.:1398397-63-1
Molecular Formula:C₂₇H₃₂N₂O₄
Molecular Weight:448.562
Hs Code.:

Synonyms:methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

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Chemical Property of methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

Chemical Property:

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Technology Process of methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

There total 4 articles about methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398395-52-2
2-(morpholin-2-yl)-N-((R)-1-(naphthalen-1-yl)ethyl)ethanamine

: 4841-23-0
(4-bromophenoxy)acetic acid methyl ester

: 1398397-63-1
methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

: 1398397-31-3
methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In toluene; at 115 ℃; for 15h; Inert atmosphere; Sealed tube;

Reference yield:

: 1005474-71-4
tert-butyl 2-(2-(tosyloxy)ethyl)morpholine-4-carboxylate

: 1398397-63-1
methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

: 1398397-31-3
methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 120 °C

2: hydrogenchloride / ethyl acetate; 1,4-dioxane / 8 h / 60 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 15 h / 115 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1398395-75-9
tert-butyl 2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholine-4-carboxylate

: 1398397-63-1
methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

: 1398397-31-3
methyl 2-(4-(2-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)phenoxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 8 h / 60 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 15 h / 115 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; ethyl acetate; toluene;