4841-23-0

Basic information

• Product Name: Methyl-(4-bromophenoxy)acetate
• Synonyms: Methyl-(4-bromophenoxy)acetate;(4-BroMophenoxy)-acetic acid Methyl ester;2-(4-bromophenoxy)acetic acid methyl ester;methyl 2-(4-bromophenoxy)ethanoate
• CAS NO: 4841-23-0
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245
• Mol File: 4841-23-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl-(4-bromophenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-(4-bromophenoxy)acetate(4841-23-0)
• EPA Substance Registry System: Methyl-(4-bromophenoxy)acetate(4841-23-0)

Safety Data

• Hazardous Substances Data: 4841-23-0(Hazardous Substances Data)

Usage

General Description

Methyl-(4-bromophenoxy)acetate is a chemical compound that belongs to the class of organic compounds known as phenol esters. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. Methyl-(4-bromophenoxy)acetate is derived from the reaction between bromophenol and acetic acid with the addition of a methyl group. Methyl-(4-bromophenoxy)acetate has a molecular formula of C9H9BrO3 and a molecular weight of 243.07 g/mol. It is known for its mild, sweet, and slightly floral odor, and is used as a fragrance ingredient in various cosmetic and personal care products. Methyl-(4-bromophenoxy)acetate may also have potential environmental and health hazards, and caution should be exercised in handling and using it.

Upstream product

• 106-41-2 4-bromo-phenol 
• 96-34-4 methyl chloroacetate 
• 96-32-2 bromoacetic acid methyl ester 
• 67-56-1 methanol 
• 1878-91-7 (4-bromophenoxy)acetic acid 

Downstream Products

• 272792-14-0 methyl 2-(4-cyanophenoxy)acetate 
• 132224-97-6 C₁₀H₁₃NO₃ 
• 178321-68-1 methyl 2-(4-ethynylphenoxy)acetate 
• 1448524-21-7 2-(4-bromophenoxy)-N-[(3-nitrophenylcarbamoyl)methyl]acetamide 
• 1448524-20-6 2-(4-bromophenoxy)-N-[(3-chlorophenylcarbamoyl)methyl]acetamide 
• 1448524-18-2 2-(4-bromophenoxy)-N-[(3-bromophenylcarbamoyl)methyl]acetamide 
• 1448524-17-1 N-[(4-bromo-2-fluorobenzylcarbamoyl)methyl]-2-(4-bromophenoxy)acetamide 
• 1448524-16-0 N-[(4-bromobenzylcarbamoyl)methyl]-2-(4-bromophenoxy)acetamide 
• 1448524-15-9 2-(4-bromophenoxy)-N-[(2-methylbenzylcarbamoyl)methyl]acetamide 

Relevant articles and documents

Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists

GSK805 (1) is a potent RORγt inverse agonist, but a drawback of 1 is its low solubility, leading to a limited absorption in high doses. We have explored detailed structure-activity relationship on the amide linker, biaryl and arylsulfonyl moieties of 1 trying to improve solubility while maintaining RORγt activity. As a result, a novel series of carboxyl-containing biaryl urea derivatives was discovered as potent RORγt inverse agonists with improved drug-like properties. Compound 3i showed potent RORγt inhibitory activity and subtype selectivity with an IC50 of 63.8 nM in RORγ FRET assay and 85 nM in cell-based RORγ-GAL4 promotor reporter assay. Reasonable inhibitory activity of 3i was also achieved in mouse Th17 cell differentiation assay (76percent inhibition at 0.3 μM). Moreover, 3i had greatly improved aqueous solubility at pH 7.4 compared to 1, exhibited decent mouse PK profile and demonstrated some in vivo efficacy in an imiquimod-induced psoriasis mice model.

New Approach to 1,4-Benzoxazin-3-ones by Electrochemical C?H Amination

1,4-Benzoxazin-3-ones are important structural motifs in natural products and bioactive compounds. Usually, the synthesis of benzoxazinones requires transition-metal catalysts and pre-functionalized substrates such as aryl halides. However, the anodic C?H

NOVEL WATER-SOLUBLE COMPLEXING AGENTS AND CORRESPONDING LANTHANIDE COMPLEXES

The invention relates to complexing agents of formula (I): in which A, chrom1, chrom2 and chrom3 are as defined in the description. The invention also relates to the lanthanide complexes obtained from these complexing agents.