5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Base Information

Chemical Name:5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol
CAS No.:1239963-97-3
Molecular Formula:C₁₉H₁₈F₂N₂OS
Molecular Weight:360.428
Hs Code.:

Synonyms:5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

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Chemical Property of 5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

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Technology Process of 5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

There total 9 articles about 5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1239963-96-2
1-(3-(4-fluoro-3-methoxyphenyl)-3-methyl-2-oxobutyl)-3-(4-fluorophenyl)thiourea

: 1239963-97-3
5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2(3H)-thione

Guidance literature:: With acetic acid; Reflux;

Reference yield:

: 1239963-91-7
2-(4-fluoro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide

: 1239963-97-3
5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether; tetrahydrofuran / 16 h / -78 - 20 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 16 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

4: hydrogenchloride; hydrogen / palladium on carbon / methanol / 2327.23 Torr

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: acetic acid / Reflux

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; acetic acid; triethylamine; palladium on carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1239963-92-8
3-(4-fluoro-3-methoxyphenyl)-3-methylbutan-2-one

: 1239963-97-3
5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 5 steps

1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 16 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

3: hydrogenchloride; hydrogen / palladium on carbon / methanol / 2327.23 Torr

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5: acetic acid / Reflux

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; acetic acid; triethylamine; palladium on carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;