2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Base Information

Chemical Name:2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole
CAS No.:1239963-52-0
Molecular Formula:C₃₅H₄₂ClF₃N₂O₃SSi
Molecular Weight:691.33
Hs Code.:

2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Synonyms:2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Chemical Property of 2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Technology Process of 2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

There total 1 articles about 2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1239963-97-3
5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

: 1239964-55-6
4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzyl methanesulfonate

: 1239963-52-0
2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: With caesium carbonate; In acetonitrile; for 2h;

Reference yield: 95.0%

: 1239963-52-0
2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 1239957-10-8
3-(3-chloro-5-fluoro-4-((5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)phenoxy)propan-1-ol

Guidance literature:: 2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole; With tetrabutyl ammonium fluoride; In tetrahydrofuran;

With acetic acid; In tetrahydrofuran;

Reference yield:

: 1239963-52-0
2-(4-(3-(tert-butyldimethylsilyloxy)propoxy)-2-chloro-6-fluorobenzylthio)-5-(2-(4-fluoro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 1239957-20-0
C₃₁H₃₃ClF₃N₇O₂S

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3: sodium azide / N,N-dimethyl-formamide / 16 h / 0 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / ethanol / 5 h / 2068.65 - 2327.23 Torr

5: butan-1-ol / 1 h / 140 °C / microwave irradiation

With hydrogenchloride; sodium azide; tetrabutyl ammonium fluoride; hydrogen; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;