tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate

Base Information

• Chemical Name: tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate
• CAS No.: 1346945-64-9
• Molecular Formula: C₂₆H₂₈N₄O₈S
• Molecular Weight: 556.596
• Mol file: 1346945-64-9.mol

Synonyms:tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate

Chemical Property of tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate

There total 3 articles about tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + N-((1R,2R)-2-amino-1,2-bis(3-nitrophenyl)ethyl)-4-methylbenzenesulfonamide (1252644-42-0) → tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate (1346945-64-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 0 - 20 ℃;

DOI:10.1016/j.tetasy.2011.08.012

Reference yield:

(1R,2R)-1,2-bis(3-nitrophenyl)ethane-1,2-diamine (1252644-48-6) → tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate (1346945-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.tetasy.2011.08.012

Reference yield:

(R,R)-1,2-diphenylethylenediamine (35132-20-8) → tert-butyl (1R,2R)-2-(4-methylphenylsulfonamido)-1,2-bis(3-nitrophenyl)ethylcarbamate (1346945-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / Cooling with ice

1.2: 2 h

1.3: pH 10

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.tetasy.2011.08.012

upstream raw materials:

di-tert-butyl dicarbonate

N-((1R,2R)-2-amino-1,2-bis(3-nitrophenyl)ethyl)-4-methylbenzenesulfonamide

(1R,2R)-1,2-bis(3-nitrophenyl)ethane-1,2-diamine

(R,R)-1,2-diphenylethylenediamine

Downstream raw materials:

tert-butyl (1R,2R)-1,2-bis(3-aminophenyl)-2-(4-methylphenylsulfonamido)ethylcarbamate

N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine