N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine

Base Information

Chemical Name:N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine
CAS No.:1346945-65-0
Molecular Formula:C₄₈H₆₈N₈O₁₂S
Molecular Weight:981.18
Hs Code.:

Synonyms:N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine

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Chemical Property of N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine

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Technology Process of N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine

There total 5 articles about N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1235572-14-1
tert-butyl (1R,2R)-1,2-bis(3-aminophenyl)-2-(4-methylphenylsulfonamido)ethylcarbamate

: 145013-05-4
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

: 1346945-65-0
N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine

Guidance literature:: With 2-bromo-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.08.012

Reference yield:

: 1252644-42-0
N-((1R,2R)-2-amino-1,2-bis(3-nitrophenyl)ethyl)-4-methylbenzenesulfonamide

: 1346945-65-0
N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3: 2-bromo-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; 2-bromo-1-methyl-pyridinium iodide; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.tetasy.2011.08.012

Reference yield:

: 1252644-48-6
(1R,2R)-1,2-bis(3-nitrophenyl)ethane-1,2-diamine

: 1346945-65-0
N-(p-toluenesulfonyl)-N-tert-butyloxycarbonyl-1,2-bis(3-(N,N'-di-tert-butyloxycarbonylguanidino)phenyl)ethylenediamine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4: 2-bromo-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; 2-bromo-1-methyl-pyridinium iodide; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.tetasy.2011.08.012