1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone

Base Information

Chemical Name:1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone
CAS No.:18461-18-2
Molecular Formula:C₁₆H₁₆N₂O
Molecular Weight:252.316
Hs Code.:

Synonyms:1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone

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Chemical Property of 1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone

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Technology Process of 1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone

There total 1 articles about 1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.2%

: 872-85-5
pyridine-4-carbaldehyde

: 2124-31-4
4'-dimethylaminoacetophenone

: 18461-18-2
1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone

Guidance literature:: With [2,2]bipyridinyl; cobalt(II) acetate; In N,N-dimethyl-formamide; at 85 ℃; for 20h;
DOI:10.1021/jm00051a013

Reference yield: 62.0%

: 18461-18-2
1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone

: 98-80-6
phenylboronic acid

: 1354807-16-1
3-(4-dimethylamino-phenyl)-3-phenyl-1-pyridin-4-yl-propan-1-one

Guidance literature:: phenylboronic acid; With diethylzinc; In hexane; toluene; at 60 ℃; Inert atmosphere;

1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone; In hexane; toluene; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 18461-18-2
1-<4-(dimethylamino)phenyl>-3-(4-pyridyl)propeneone

: (-)-(R,E)-3-(4-dimethylamino-phenyl)-3-phenyl-1-pyridin-4-yl-propan-1-one oxime

: (+)-(S,E)-3-(4-dimethylamino-phenyl)-3-phenyl-1-pyridin-4-yl-propan-1-one oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylzinc / toluene; hexane / 60 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 2 h / Reflux

3.1: Chiralpak AD / n-heptane; ethanol / Resolution of racemate

With hydroxylamine hydrochloride; diethylzinc; sodium hydrogencarbonate; In ethanol; hexane; n-heptane; water; toluene; 1.2: Negishi Coupling Reaction;