(S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide

Base Information

Chemical Name:(S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide
CAS No.:111087-84-4
Molecular Formula:BrH*2C₂₁H₁₇I₂NO₅
Molecular Weight:1315.27
Hs Code.:

Synonyms:(S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide

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Chemical Property of (S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide

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Technology Process of (S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide

There total 8 articles about (S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 111087-84-4
(S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide

Guidance literature:: Multi-step reaction with 7 steps

2: NaOH, adogen 464 / CH₂Cl₂; H₂O / 2.5 h

4: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

5: H₂ / Pd/C / acetic acid

6: 1.) NaNO₂, H₂SO₄, 2.) I₂, KI / 1.) H₂O, -7 deg C, 2.) CHCl₃, 1.5 h

7: HBr, HOAc

With sodium hydroxide; adogen 464; sulfuric acid; hydrogen bromide; hydrogen; iodine; acetic acid; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In dichloromethane; water; acetic acid;
DOI:10.1021/jm00396a008

Reference yield:

: 63801-89-8
4-hydroxy-3-(4-methoxyphenyl)nitrobenzene

: 111087-84-4
(S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH, adogen 464 / CH₂Cl₂; H₂O / 2.5 h

3: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

4: H₂ / Pd/C / acetic acid

5: 1.) NaNO₂, H₂SO₄, 2.) I₂, KI / 1.) H₂O, -7 deg C, 2.) CHCl₃, 1.5 h

6: HBr, HOAc

With sodium hydroxide; adogen 464; sulfuric acid; hydrogen bromide; hydrogen; iodine; acetic acid; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In dichloromethane; water; acetic acid;
DOI:10.1021/jm00396a008

Reference yield:

: 103594-25-8
4-methoxy-3-(4-methoxyphenyl)phenol

: 111087-84-4
(S)-2-Amino-3-[4-(6,4'-dihydroxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-propionic acid; hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

2: H₂ / Pd/C / acetic acid

3: 1.) NaNO₂, H₂SO₄, 2.) I₂, KI / 1.) H₂O, -7 deg C, 2.) CHCl₃, 1.5 h

4: HBr, HOAc

With sulfuric acid; hydrogen bromide; hydrogen; iodine; acetic acid; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In acetic acid;
DOI:10.1021/jm00396a008