(S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

Base Information

Chemical Name:(S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester
CAS No.:111088-13-2
Molecular Formula:C₂₇H₂₄F₃I₂NO₆
Molecular Weight:769.295
Hs Code.:

Synonyms:(S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

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Chemical Property of (S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

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Technology Process of (S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

There total 7 articles about (S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 111088-13-2
(S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

2: NaOH, adogen 464 / CH₂Cl₂; H₂O / 2.5 h

4: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

5: H₂ / Pd/C / acetic acid

6: 1.) NaNO₂, H₂SO₄, 2.) I₂, KI / 1.) H₂O, -7 deg C, 2.) CHCl₃, 1.5 h

With sodium hydroxide; adogen 464; sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In dichloromethane; water; acetic acid;
DOI:10.1021/jm00396a008

Reference yield:

: 63801-89-8
4-hydroxy-3-(4-methoxyphenyl)nitrobenzene

: 111088-13-2
(S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH, adogen 464 / CH₂Cl₂; H₂O / 2.5 h

3: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

4: H₂ / Pd/C / acetic acid

5: 1.) NaNO₂, H₂SO₄, 2.) I₂, KI / 1.) H₂O, -7 deg C, 2.) CHCl₃, 1.5 h

With sodium hydroxide; adogen 464; sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In dichloromethane; water; acetic acid;
DOI:10.1021/jm00396a008

Reference yield:

: 103594-25-8
4-methoxy-3-(4-methoxyphenyl)phenol

: 111088-13-2
(S)-3-[4-(6,4'-Dimethoxy-biphenyl-3-yloxy)-3,5-diiodo-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

2: H₂ / Pd/C / acetic acid

3: 1.) NaNO₂, H₂SO₄, 2.) I₂, KI / 1.) H₂O, -7 deg C, 2.) CHCl₃, 1.5 h

With sulfuric acid; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In acetic acid;
DOI:10.1021/jm00396a008