2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

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Chemical Name:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride
CAS No.:1301659-88-0
Molecular Formula:C₃₀H₂₈F₇N₃O₃*ClH
Molecular Weight:648.02
Hs Code.:

2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

Synonyms:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

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Chemical Property of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

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Technology Process of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

There total 11 articles about 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301659-93-7
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

: 1301659-88-0
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 0 ℃; for 0.166667h;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301659-88-0
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: hydrogen / Raney-Ni / ethanol; water / 4 h

6.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

7.2: 0.25 h / -78 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: calcium chloride; sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

9.2: pH 3 - 4

10.1: Chiralpak AD-H / hexane; ethanol / Resolution of racemate

11.1: hydrogenchloride / dichloromethane; diethyl ether / 0.17 h / 0 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; osmium(VIII) oxide; water; hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-58-1
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-propenoate

: 1301659-88-0
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

2.1: hydrogen / Raney-Ni / ethanol; water / 4 h

3.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

4.2: 0.25 h / -78 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: calcium chloride; sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

6.2: pH 3 - 4

7.1: Chiralpak AD-H / hexane; ethanol / Resolution of racemate

8.1: hydrogenchloride / dichloromethane; diethyl ether / 0.17 h / 0 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; calcium chloride; lithium hexamethyldisilazane; Raney-Ni; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water;