825643-73-0

Usage

Chemical structure

A synthetic nucleoside analogue

Function

Antiviral and anticancer medication

Mechanism of action

Inhibits the replication of viral and cancerous DNA within infected or abnormal cells, leading to their destruction

Common uses

Treatment of herpes simplex keratitis (a viral infection of the eye) and certain types of cancer, particularly colorectal and gastrointestinal cancers

Administration

Eye drop or injection under expert medical supervision

Precautions

Potent and potentially harmful effects if not used properly

Upstream product

• 400777-00-6 (6-chloro-4-iodopyridin-3-yl)carbamic acid tert-butyl ester 
• 825643-58-1 (6-chloro-4-iodopyridine-3-yl)methylcarbamic acid tert-butyl ester 
• 825643-59-2 (6-chloro-4-iodopyridin-3-yl) methylamine 
• 289686-69-7 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride 
• 74-88-4 methyl iodide 
• 171178-45-3 tert-butyl (6-chloropyridin-3-yl)carbamate 
• 289686-70-0 α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 

Downstream Products

• 825640-97-9 (2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide 
• 825644-79-9 (R)-N-[6-(4-benzyl-2-methyl-piperazin-1-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide 
• 929047-74-5 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(octahydro-2H-pyrazino[1,2-a]pyrazin-2-yl)-3-pyridinyl]-N,2-dimethylpropanamide 
• 929046-17-3 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-3-pyridinyl]-N,2-dimethylpropanamide 
• 929047-61-0 2-[3,5-bis(trifluoromethyl)phenyl]-N-(4-(4-fluoro-2-methylphenyl)-6-{[(2S)-2-pyrrolidinylmethyl]amino}-3-pyridinyl)-N,2-dimethylpropanamide 

Relevant academic research and scientific papers

NEW CHEMICAL PROCESS FOR MAKING 6-CHLORO-4-(4-FLUORO-2-METHYLPHENYL)PYRIDIN-3-AMINE A KEY INTERMEDIATE OF NT-814

The invention relates to a new process for producing compound 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide (Compound IX) which is useful in the manufacture of compound 2-[3,5-Bis(trifluoro

CARBOXYMETHYL PIPERIDINE DERIVATIVE

The present invention provides a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to carboxymethyl piperidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. Wherein, ring A is a benzene ring or the like; ring B is a pyridine ring or the like; R1 is C1-6 alkyl or C1-6 alkoxy; R2 and R3 are a hydrogen atom or methyl; and n is an integral number from 0 to 5.

Cyclohexylpropionic polypyridine deriv.

A problem of the present invention is to provide a new compound which has NK 1 receptor antagonist activity ,whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R 1 is carboxymethyl or the like; R 2 is alkyl or the like; Y is 0-2 or the like; U is-N(CH 3 )COC(CH 3 ) 2 -3,5-bistrifluoromethylphenyl or the like.

Carboxymethyl piperidine derivative

The present invention provides a novel compound useful in the prevention or treatment of nausea and vomiting associated with the administration of antineoplastics, the compound having an NK1 receptor-antagonizing effect, and an inhibitory effect on CYP3A4 that is attenuated to a greater extent than in aprepitant. Specifically, the present invention relates to a carboxymethyl piperidine derivative represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, ring A is a benzene ring or the like, ring B is a pyridine ring or the like, R1 is a C1-6 alkyl or C1-6 alkoxy, R2 and R3 are hydrogen atoms or methyl, and n represents an integer of from 0 to 5.

Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia

The present invention relates to a method of treating schizophrenia which comprises administering a therapeutically effective amount of a compound of formula I wherein R1, R2, and R3 are as defined in the specification or to pharmaceutically active acid-addition salts thereof.

DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA

The use of compounds of the general formula wherein the substituents are as described in claim 1 or pharmaceutically active acid-addition salts thereof for the preparation of medicaments for the treatment of schizophrenia.

Substituted 4-phenyl-pyridine compounds with activity as antagonists of neurokinin 1 receptors

Substituted 4-phenyl-pyridine compounds with activity as antagonists of Neurokinin 1 receptors, methods of making these compounds and preparing.