8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

Base Information

Chemical Name:8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide
CAS No.:1351945-31-7
Molecular Formula:C₂₅H₁₇F₃N₂O₃
Molecular Weight:450.417
Hs Code.:

Synonyms:8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

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Chemical Property of 8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

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Technology Process of 8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

There total 6 articles about 8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(trifluoromethyl)biphenyl-4-amine

: 1351945-31-7
8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 17 h / 60 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride / 1,4-dioxane / 16 h / 50 °C / Inert atmosphere

3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

4: sodium periodate / water; acetone / 20 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methylmorpholine N-oxide; triethylamine; cesium fluoride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ml200252b

Reference yield:

: 1351945-29-3
8-ethenyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

: 1351945-31-7
8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

2: sodium periodate / water; acetone / 20 °C

With sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone;
DOI:10.1021/ml200252b

Reference yield:

: 1351945-28-2
8-chloro-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

: 1351945-31-7
8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride / 1,4-dioxane / 16 h / 50 °C / Inert atmosphere

2: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

3: sodium periodate / water; acetone / 20 °C

With sodium periodate; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 4-methylmorpholine N-oxide; cesium fluoride; In 1,4-dioxane; water; acetone;
DOI:10.1021/ml200252b