1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid

Base Information

Chemical Name:1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid
CAS No.:1351945-13-5
Molecular Formula:C₂₅H₁₇F₃N₂O₄
Molecular Weight:466.416
Hs Code.:

Synonyms:1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid

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Chemical Property of 1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid

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Technology Process of 1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid

There total 8 articles about 1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1351945-31-7
8-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenyl-4-yl)-1,4-dihydro-3-quinolinecarboxamide

: 1351945-13-5
1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol; at 0 - 20 ℃; for 24h;
DOI:10.1021/ml200252b

Reference yield:

: 1351945-28-2
8-chloro-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

: 1351945-13-5
1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride / 1,4-dioxane / 16 h / 50 °C / Inert atmosphere

2: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

3: sodium periodate / water; acetone / 20 °C

4: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol / 24 h / 0 - 20 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 4-methylmorpholine N-oxide; cesium fluoride; In 1,4-dioxane; water; acetone; tert-butyl alcohol;
DOI:10.1021/ml200252b

Reference yield:

: 2-(trifluoromethyl)biphenyl-4-amine

: 1351945-13-5
1-methyl-4-oxo-3-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)-1,4-dihydroquinoline-8-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 17 h / 60 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride / 1,4-dioxane / 16 h / 50 °C / Inert atmosphere

3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

4: sodium periodate / water; acetone / 20 °C

5: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tert-butyl alcohol / 24 h / 0 - 20 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; bis(tri-t-butylphosphine)palladium⁽⁰⁾; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methylmorpholine N-oxide; triethylamine; cesium fluoride; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/ml200252b