methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate

Base Information

Chemical Name:methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate
CAS No.:1050596-39-8
Molecular Formula:C₂HF₃O₂*C₂₃H₂₅Cl₂NO₆
Molecular Weight:596.385
Hs Code.:

Synonyms:methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate

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Chemical Property of methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate

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Technology Process of methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate

There total 2 articles about methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 644971-06-2
methyl 5-chloro-4-[(4-methoxybenzyl)oxy]-2-[(2S)-oxiran-2-ylmethoxy]benzoate

: 71916-97-7
5-chloro-2,3-dihydrospiro

: 76-05-1
trifluoroacetic acid

: 1050596-39-8
methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate

Guidance literature:: methyl 5-chloro-4-[(4-methoxybenzyl)oxy]-2-[(2S)-oxiran-2-ylmethoxy]benzoate; 5-chloro-2,3-dihydrospiro; In ethanol; at 80 ℃; for 18h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

: 644971-05-1
5-chloro-2-hydroxy-4-(4-methoxybenzyloxy)benzoic acid methyl ester

: 1050596-39-8
methyl 5-chloro-2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxybenzoate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: ethanol / 18 h / 80 °C

2.2: 2.5 h / 20 °C

With caesium carbonate; In ethanol; N,N-dimethyl-formamide;