allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate

Base Information

• Chemical Name: allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate
• CAS No.: 1275617-03-2
• Molecular Formula: C₃₀H₄₅BrN₄O₈SSi
• Molecular Weight: 729.765
• Mol file: 1275617-03-2.mol

Synonyms:allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate

Chemical Property of allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate

There total 12 articles about allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C49H59BrN4O8SSi → allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate (1275617-03-2)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jm1014023

Reference yield:

allyl 2-[(R)-2-amino-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-6-bromo-3-[dimethyl(thexyl)silyloxy]-5-methoxybenzoate (1275617-08-7) → allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate (1275617-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,2-dichloro-ethane / acetonitrile / 5 h / 0 °C / Inert atmosphere

2: trifluoroacetic acid / 0.17 h / 20 °C / Inert atmosphere

3: benzotriazol-1-ol; 1,2-dichloro-ethane / methanol; acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

4: toluene-4-sulfonic acid / methanol; dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; toluene-4-sulfonic acid; 1,2-dichloro-ethane; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm1014023

Reference yield:

C33H51BrN4O8SSi → allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-{2-[(2-hydroxyacetyl)methylamino]acetylamino}-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-3-methylbenzoate (1275617-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / 0.17 h / 20 °C / Inert atmosphere

2: benzotriazol-1-ol; 1,2-dichloro-ethane / methanol; acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / methanol; dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; toluene-4-sulfonic acid; 1,2-dichloro-ethane; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/jm1014023

upstream raw materials:

allyl 2-[(R)-2-amino-2-(3-methyl-1,2,4-oxadiazol-5-yl)ethylsulfanylmethyl]-6-bromo-3-[dimethyl(thexyl)silyloxy]-5-methoxybenzoate

allyl 2-bromo-5-[dimethyl(thexyl)silyloxy]-3-methoxy-6-[(R)-2-(2-methylaminoacetylamino)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-ethylsulfanylmethyl]benzoate

(RS)-3,4-dihydroxy-6-methoxy-3H-isobenzofuran-1-one

(RS)-7-bromo-3,4-dihydroxy-6-methoxy-3H-isobenzofuran-1-one