methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate

Base Information

Chemical Name:methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate
CAS No.:474432-84-3
Molecular Formula:C₁₉H₂₂N₂O₅
Molecular Weight:358.394
Hs Code.:

Synonyms:methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate

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Chemical Property of methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate

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Technology Process of methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate

There total 1 articles about methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 78553-47-6
methyl (2S)-2-[N-(benzyloxycarbonyl)amino]pent-4-enoate

: 206860-49-3
2-bromopyridine-N-oxide hydrobromide

: 474432-84-3
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate

Guidance literature:: methyl (2S)-2-[N-(benzyloxycarbonyl)amino]pent-4-enoate; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 20 ℃;

2-bromopyridine-N-oxide hydrobromide; With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 65 ℃;
DOI:10.1016/S0040-4020(02)00541-0

Reference yield: 62.0%

: 474432-84-3
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate

: 474432-85-4
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-hydroxy-5-(2-pyridinyl)pentanoate

Guidance literature:: methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate; With trifluoroacetic anhydride; In dichloromethane; at 20 ℃;

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 3h;
DOI:10.1016/S0040-4020(02)00541-0

Reference yield:

: 474432-84-3
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-(1-oxo-2-pyridinyl)pentanoate

: 474432-88-7
(S)-2-Benzyloxycarbonylamino-5-oxo-5-pyridin-2-yl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride / CH₂Cl₂ / 20 °C

1.2: 62 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 3 h / 20 °C

2.1: 71 percent / MnO₂ / 20 °C

With manganese(IV) oxide; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1016/S0040-4020(02)00541-0