3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole

Base Information

Chemical Name:3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole
CAS No.:1603830-28-9
Molecular Formula:C₂₃H₁₇FN₄O
Molecular Weight:384.413
Hs Code.:

Synonyms:3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole

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Chemical Property of 3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole

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Technology Process of 3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole

There total 7 articles about 3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85979-59-5
2-chloro-4-(4-fluorophenyl)-pyrimidine

: 1603830-26-7
(9-methyl-9H-pyrido[2,3-b]indol-3-yl)methanol

: 1603830-28-9
3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole

Guidance literature:: With caesium carbonate; In water; dimethyl sulfoxide; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.bmcl.2014.03.054

Reference yield:

: 139884-24-5
9-methyl-<9H>-pyrido<2,3-b>indole-3-carbonitrile

: 1603830-28-9
3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

2: sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

3: caesium carbonate / dimethyl sulfoxide; water / 12 h / 80 °C / Inert atmosphere; Schlenk technique

With sodium tetrahydroborate; diisobutylaluminium hydride; caesium carbonate; In methanol; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmcl.2014.03.054

Reference yield:

: 1603830-25-6
9-methyl-9H-pyrido[2,3-b]indole-3-carbaldehyde

: 1603830-28-9
3-({[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}methyl)-9-methyl-9H-pyrido[2,3-b]indole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: caesium carbonate / dimethyl sulfoxide; water / 12 h / 80 °C / Inert atmosphere; Schlenk technique

With sodium tetrahydroborate; caesium carbonate; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2014.03.054