((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Base Information

Chemical Name:((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate
CAS No.:1584714-49-7
Molecular Formula:C₃₅H₃₅F₄N₄O₉P
Molecular Weight:762.652
Hs Code.:

((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Synonyms:((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

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Chemical Property of ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

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Technology Process of ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

There total 5 articles about ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1584715-61-6
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

: 1584714-49-7
((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.583333h;

Reference yield:

: 1351831-47-4
methyl 2-(4-((di-tert-butoxyphosphoryl)-oxy)phenyl)acetate

: 1584714-49-7
((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

2.1: triethylamine hydrochloride; sulfuryl dichloride / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 1.17 h / 20 °C / Inert atmosphere

2.3: Berger SFC MGII / Supercritical conditions; liquid CO₂

3.1: trifluoroacetic acid / dichloromethane / 0.58 h / 0 - 20 °C

With sulfuryl dichloride; water; triethylamine hydrochloride; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1584714-49-7
((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-tetrazole / acetonitrile / 0.58 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

3.1: triethylamine hydrochloride; sulfuryl dichloride / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

3.2: 1.17 h / 20 °C / Inert atmosphere

3.3: Berger SFC MGII / Supercritical conditions; liquid CO₂

4.1: trifluoroacetic acid / dichloromethane / 0.58 h / 0 - 20 °C

With 1H-tetrazole; sulfuryl dichloride; water; triethylamine hydrochloride; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;