((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

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Chemical Name:((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate
CAS No.:1584715-61-6
Molecular Formula:C₄₃H₅₁F₄N₄O₉P
Molecular Weight:874.867
Hs Code.:

((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

Synonyms:((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

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Chemical Property of ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

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Technology Process of ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

There total 5 articles about ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1351831-48-5
2-(4-((di-tert-butoxyphosphoryl)-oxy)phenyl)acetic acid

: (2R,3S)-3-(cyclopropylmethyl)-N₁-((S)-9-fluoro-1-(methylthiomethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

: 1584715-61-6
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

Guidance literature:: (2R,3S)-3-(cyclopropylmethyl)-N₁-((S)-9-fluoro-1-(methylthiomethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide; With sulfuryl dichloride; triethylamine hydrochloride; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

2-(4-((di-tert-butoxyphosphoryl)-oxy)phenyl)acetic acid; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1.16667h; Inert atmosphere;

In methanol; carbon dioxide; Supercritical conditions; liquid CO₂;

Reference yield:

: 1351831-47-4
methyl 2-(4-((di-tert-butoxyphosphoryl)-oxy)phenyl)acetate

: 1584715-61-6
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

2.1: triethylamine hydrochloride; sulfuryl dichloride / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 1.17 h / 20 °C / Inert atmosphere

2.3: Berger SFC MGII / Supercritical conditions; liquid CO₂

With sulfuryl dichloride; water; triethylamine hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: C₂₆H₂₆F₄N₄O₃

: 1584715-61-6
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl 2-(4-(di-tert-butoxyphosphoryloxy)-2-fluorophenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.92 h / 20 °C / Inert atmosphere

2.1: triethylamine hydrochloride; sulfuryl dichloride / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 1.17 h / 20 °C / Inert atmosphere

2.3: Berger SFC MGII / Supercritical conditions; liquid CO₂

With sulfuryl dichloride; triethylamine hydrochloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;