(3R,αR)-ethyl 3-hexanoate

Base Information

• Chemical Name: (3R,αR)-ethyl 3-hexanoate
• CAS No.: 103123-64-4
• Molecular Formula: C₁₆H₂₅NO₂
• Molecular Weight: 263.38
• Mol file: 103123-64-4.mol

Synonyms:(3R,αR)-ethyl 3-hexanoate

Chemical Property of (3R,αR)-ethyl 3-hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,αR)-ethyl 3-hexanoate

There total 4 articles about (3R,αR)-ethyl 3-hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(Z)-3-((R)-1-Phenyl-ethylamino)-hex-2-enoic acid ethyl ester → (3R,αR)-ethyl 3-hexanoate (103123-64-4) + (3S,αR)-ethyl 3-hexanoate

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetic acid; acetonitrile; at 0 ℃; for 4h;

DOI:10.1021/jo960107y

Reference yield: 63.0%

(3R,7R)-ethyl N-(α-methylbenzyl benzyl)-3-aminohexanoate (222425-48-1) → (3R,αR)-ethyl 3-hexanoate (103123-64-4)

Guidance literature:

With ammonium cerium(IV) nitrate; water; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2005.12.030

Reference yield:

ethyl (E)-hex-2-enoate (27829-72-7) → (3R,αR)-ethyl 3-hexanoate (103123-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

2: 63 percent / ceric ammonium nitrate; H₂O / acetonitrile / 1 h / 20 °C

With n-butyllithium; ammonium cerium(IV) nitrate; water; In tetrahydrofuran; hexane; acetonitrile;

DOI:10.1016/j.tet.2005.12.030

upstream raw materials:

(3R,7R)-ethyl N-(α-methylbenzyl benzyl)-3-aminohexanoate

ethyl (E)-hex-2-enoate

(R)-N-benzyl-1-phenylethylamine

Downstream raw materials:

(2S,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)hexanoate

(2R,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)hexanoate