222425-48-1

Basic information

• Product Name: Hexanoic acid, 3-[[(1R)-1-phenylethyl](phenylmethyl)amino]-, ethyl ester, (3R)-
• CAS NO: 222425-48-1
• Molecular Formula: C23H31NO2
• Molecular Weight: 353.505
• Mol File: 222425-48-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Hexanoic acid, 3-[[(1R)-1-phenylethyl](phenylmethyl)amino]-, ethyl ester, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanoic acid, 3-[[(1R)-1-phenylethyl](phenylmethyl)amino]-, ethyl ester, (3R)-(222425-48-1)
• EPA Substance Registry System: Hexanoic acid, 3-[[(1R)-1-phenylethyl](phenylmethyl)amino]-, ethyl ester, (3R)-(222425-48-1)

Safety Data

• Hazardous Substances Data: 222425-48-1(Hazardous Substances Data)

Upstream product

• 27829-72-7 ethyl (E)-hex-2-enoate 
• 38235-77-7 (R)-N-benzyl-1-phenylethylamine 

Downstream Products

• 884318-88-1 (2R,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)hexanoate 
• 884318-87-0 (2S,3R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)hexanoate 
• 103123-64-4 (3R,αR)-ethyl 3-hexanoate 
• 602275-69-4 (R)-4-[Benzyl-((R)-1-phenyl-ethyl)-amino]-1-trimethylsilanyl-2-trimethylsilanylmethyl-heptan-2-ol 

Relevant articles and documents

Enantioselective synthesis of (-)-indolizidine 167B

The enantioselective total synthesis of (-)-indolizidine 167B is described. The key step is the intramolecular cyclization of the chiral N- acyliminium ion 6. Indolizidine 167B was obtained in 7 steps and 17% yield from ethyl (R)-3-aminohexanoate, with an

Isolation and Structure Determination of Lyngbyastatin 3, a Lyngbyastatin 1 Homologue from the Marine Cyanobacterium Lyngbya majuscula. Determination of the Configuration of the 4-Amino-2,2-dimethyl-3-oxopentanoic Acid Unit in Majusculamide C, Dolastatin 12, Lyngbyastatin 1, and Lyngbyastatin 3 from Cyanobacteria

The structure of lyngbyastatin 3 (1), including the configurations of the two unusual amino acid residues, viz., the 3-amino-2-methylhexanoic acid (Amha) and 4-amino-2,2-dimethyl-3-oxopentanoic acid units (Ibu), has been established by chemical degradation. Analysis of the cyanobacterial samples of lyngbyastatin 3 (1), lyngbyastatin 1 (2), and dolastatin 12 (3) demonstrated that they are mixtures of Ibu epimers [R (major) and S (minor)], whereas the structurally related majusculamide C (4) is a single diastereomer having an S-Ibu unit.