2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate

Base Information

Chemical Name:2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate
CAS No.:1300746-16-0
Molecular Formula:C₂HF₃O₂*C₂₃H₂₅ClN₆O₂
Molecular Weight:566.967
Hs Code.:

Synonyms:2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate

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Chemical Property of 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate

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Technology Process of 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate

There total 11 articles about 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1300746-69-3
1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

: 76-05-1
trifluoroacetic acid

: 1300746-16-0
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate

Guidance literature:: In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1300746-16-0
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene; diethyl ether / 1 h / 0 - 20 °C

1.2: 2 h / Reflux

2.1: chloroform / 1.5 h / 60 °C

3.1: triethylamine / dichloromethane / 24 h / Reflux

3.2: 2 h / 60 °C

4.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

5.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

5.2: 1 h / 20 °C

6.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

9.1: dichloromethane / 2 h / 25 °C / Inert atmosphere

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1300746-16-0
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-[2-(methylamino)ethyl]acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2.25 h / Reflux

2.1: toluene; diethyl ether / 1 h / 0 - 20 °C

2.2: 2 h / Reflux

3.1: chloroform / 1.5 h / 60 °C

4.1: triethylamine / dichloromethane / 24 h / Reflux

4.2: 2 h / 60 °C

5.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

6.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

6.2: 1 h / 20 °C

7.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

8.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

10.1: dichloromethane / 2 h / 25 °C / Inert atmosphere

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;