1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

Base Information

Chemical Name:1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate
CAS No.:1300746-69-3
Molecular Formula:C₂₈H₃₃ClN₆O₄
Molecular Weight:553.061
Hs Code.:

1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

Synonyms:1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

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Chemical Property of 1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

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Technology Process of 1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

There total 10 articles about 1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300019-38-8
[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

: 121492-06-6
(2-aminoethyl)methylcarbamic acid tert-butyl ester

: 1300746-69-3
1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1300746-69-3
1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene; diethyl ether / 1 h / 0 - 20 °C

1.2: 2 h / Reflux

2.1: chloroform / 1.5 h / 60 °C

3.1: triethylamine / dichloromethane / 24 h / Reflux

3.2: 2 h / 60 °C

4.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

5.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

5.2: 1 h / 20 °C

6.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 38527-50-3
2-methyl-6-(methoxy)-3,1-benzoxazin-4-one

: 1300746-69-3
1,1-dimethylethyl [2-({[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetyl}amino)ethyl]methylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene; diethyl ether / 1 h / 0 - 20 °C

1.2: 2 h / Reflux

2.1: chloroform / 1.5 h / 60 °C

3.1: triethylamine / dichloromethane / 24 h / Reflux

3.2: 2 h / 60 °C

4.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

5.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

5.2: 1 h / 20 °C

6.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;