(4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Base Information

Chemical Name:(4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone
CAS No.:1362020-48-1
Molecular Formula:C₂₁H₂₂ClN₅O₂
Molecular Weight:411.891
Hs Code.:

Synonyms:(4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

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Chemical Property of (4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

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Technology Process of (4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

There total 4 articles about (4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

: 39512-50-0
N-(o-Chlorophenyl)piperazine

: 1362020-68-5
C₁₁H₁₁N₃O₃

: 1362020-48-1
(4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm2013503

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 1362020-48-1
(4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; ethyl acetate / 0.17 h / 0 °C

1.2: 0.5 h

1.3: 0.5 h / 0 °C

2.1: toluene / 120 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/jm2013503

Reference yield:

: 1362020-54-9
C₁₃H₁₅N₃O₃

: 1362020-48-1
(4-(2-chlorophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 3 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm2013503