2-Methoxyphenyl azide

Base Information

• Chemical Name: 2-Methoxyphenyl azide
• CAS No.: 20442-97-1
• Molecular Formula: C7H7N3O
• Molecular Weight: 149.152
• Hs Code.: 2929909090
• Mol file: 20442-97-1.mol

Synonyms:2-Methoxyphenyl azide;Anisole,o-azido;o-methoxyphenyl azide;1-azido-2-methoxy-benzene;2-azidophenyl methyl ether;2-MeOC6H4N3;2-Azidoanisole solution;Benzene,1-azido-2-methoxy;2-Azidoanisole;

Chemical Property of 2-Methoxyphenyl azide

Chemical Property:

• Melting Point: 82-84 °C
• Flash Point: -33℃
• PSA: 58.98000
• LogP: 2.08976
• Storage Temp.: ?20°C

Purity/Quality:

1-azido-2-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 2091723
• Hazard Codes: F,T
• Statements: 11-38-48/23/24/25
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxyphenyl azide

There total 12 articles about 2-Methoxyphenyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-phenylamine (90-04-0) → 2-methoxylphenyl azide (20442-97-1)

Guidance literature:

With tert.-butylnitrite; trimethylsilylazide; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0034-1379887

Reference yield: 90.0%

2-Methoxyphenylboronic acid (5720-06-9) → 2-methoxylphenyl azide (20442-97-1)

Guidance literature:

With sodium azide; copper(II) sulfate; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2007.03.107

Reference yield: 87.0%

o-Methoxyphenyllead(IV) triacetate (68490-98-2) → 2-methoxylphenyl azide (20442-97-1)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; for 3h; Ambient temperature;

upstream raw materials:

2-methoxy-phenylamine

o-Methoxyphenyllead(IV) triacetate

(2-methoxyphenyl)hydrazine

4-iodoanisol

Downstream raw materials:

Ortho-(P,P,P-triethoxy-phosphinimido)-anisol

2-methoxy-phenylamine

1-(2-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

[Pd(κ(2)-C6H3MeN2C6H4CH3-C,N')(κ(2)-Ph2PCH2P(=NC6H4OMe-2)Ph2-P,N)]OSO2CF3

Refernces

• 1、 Montalvo-Acosta, Joel J.,Dryzhakov, Marian,Richmond, Edward,Cecchini, Marco,Moran, Joseph. "A Supramolecular Model for the Co-Catalytic Role of Nitro Compounds in Br?nsted Acid Catalyzed Reactions". . p. 10976 - 10980. Retrieved 2020.
• 2、 Akolkar, Satish V.,Khedkar, Vijay M.,Nagargoje, Amol A.,Pisal, Parshuram M.,Sangshetti, Jaiprakash N.,Shingate, Bapurao B.,Siddiqui, Madiha M.. "[HDBU][HSO4]-catalyzed facile synthesis of new 1,2,3-triazole-tethered 2,3-dihydroquinazolin-4[1H]-one derivatives and their DPPH radical scavenging activity". . . Retrieved 2022/01/19.
• 3、 Gibault, Floriane,Sturbaut, Manon,Coevoet, Mathilde,Pugnière, Martine,Burtscher, Ashley,Allemand, Frédéric,Melnyk, Patricia,Hong, Wanjin,Rubin, Brian P.,Pobbati, Ajaybabu V.,Guichou, Jean-Fran?ois,Cotelle, Philippe,Bailly, Fabrice. "Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex". . p. 2823 - 2844. Retrieved 2021/07/10.