(2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

Base Information

Chemical Name:(2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol
CAS No.:1452816-26-0
Molecular Formula:C₃₁H₄₂O₃Si
Molecular Weight:490.758
Hs Code.:

Synonyms:(2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

Suppliers and Price of (2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

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Technology Process of (2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

There total 6 articles about (2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1452816-20-4
(2R,3R)-E-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhex-4-en-3-ol

: 1452816-26-0
(2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

Guidance literature:: With C₃₈H₅₆IrN₃O⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); hydrogen; In dichloromethane; for 4h; under 37503.8 Torr;
DOI:10.1002/adsc.201200709

Reference yield:

: 1452816-20-4
(2R,3R)-E-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhex-4-en-3-ol

: (2R,3S,4R)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

: 1452816-26-0
(2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

Guidance literature:: With C₃₈H₅₄IrN₃O*C₃₂H₁₂BF₂₄^(1-); hydrogen; In dichloromethane; under 37503.8 Torr;
DOI:10.1002/adsc.201200709

Reference yield:

: 443752-42-9
[4-(tert-butyl-diphenyl-silanyloxy)-1,3-dimethyl-2-oxo-butyl]-phosphonic acid diethyl ester

: 1452816-26-0
(2R,3S,4S)-6-(benzyloxy)-1-[(tert-butyldiphenylsilyl)-oxy]-2,4-dimethylhexan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: barium(II) hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C

1.2: 2 h / 25 °C

2.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

3.1: C₃₈H₅₄IrN₃O*C₃₂H₁₂BF₂₄^(1-); hydrogen / dichloromethane / 37503.8 Torr

With C₃₈H₅₄IrN₃O*C₃₂H₁₂BF₂₄^(1-); hydrogen; diisobutylaluminium hydride; barium(II) hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1002/adsc.201200709