443752-42-9Relevant academic research and scientific papers
Highly stereoselective syntheses of all 1,2,3-Me,OH,Me triads via asymmetric hydrogenation reactions
Zhu, Ye,Burgess, Kevin
, p. 107 - 115 (2013/03/14)
Iridium-catalyzed asymmetric hydrogenations of chiral alkenes were used to access four pivotal α,ω-functionalized chirons, that contain widely occurring stereochemical 1,2,3-Me,OH,Me motifs. A chiral analogue of Crabtree's catalyst was used in key hydrogenation steps to form these motifs with high stereochemical purities. An application of one of these chirons is illustrated here with a synthesis of (-)-invictolide. Copyright
Studies directed toward the synthesis of the C15-C21 fragment of (-)-discodermolide
Chakraborty, Tushar K.,Laxman, Pasunoori
, p. 543 - 545 (2007/10/03)
A novel method developed by us recently for the synthesis of chiral 2-methyl-1,3-diols by radical-mediated diastereoselective opening of trisubstituted epoxy alcohols at the more substituted carbon serves as the key step in our studies directed toward the
