N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide

Base Information

Chemical Name:N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide
CAS No.:1190643-36-7
Molecular Formula:C₂₂H₂₅ClN₂O₃S
Molecular Weight:432.971
Hs Code.:

Synonyms:N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide

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Chemical Property of N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide

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Technology Process of N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide

There total 6 articles about N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1190643-34-5
2-(1-(1-(4-chlorophenyl)cyclobutyl)-3,4-dihydroisoquinolin-7-yloxy)ethanamine

: 124-63-0
methanesulfonyl chloride

: 1190643-36-7
N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide

Guidance literature:: With 2-aminopyridine; In tetrahydrofuran; at 20 ℃; for 14h;

Reference yield:

: 916923-23-4
1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide

: 1190643-36-7
N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / toluene / 8 h / Reflux

2.1: water; hydrogen bromide / 4 h / 120 °C

2.2: pH 10

3.1: sodium hydride / N,N-dimethyl acetamide / 20 °C

4.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 14 h

5.1: 2-aminopyridine / tetrahydrofuran / 14 h / 20 °C

With 2-aminopyridine; hydrogenchloride; water; hydrogen bromide; sodium hydride; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol; toluene;

Reference yield:

: 1190644-17-7
1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-ol

: 1190643-36-7
N-(2-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-ethyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl acetamide / 20 °C

2: hydrogenchloride / dichloromethane; isopropyl alcohol / 14 h

3: 2-aminopyridine / tetrahydrofuran / 14 h / 20 °C

With 2-aminopyridine; hydrogenchloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol;