C₂₂H₂₁NO

Base Information

• Chemical Name: C₂₂H₂₁NO
• CAS No.: 1391713-31-7
• Molecular Formula: C₂₂H₂₁NO
• Molecular Weight: 315.415
• Mol file: 1391713-31-7.mol

Synonyms:C₂₂H₂₁NO

Chemical Property of C₂₂H₂₁NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₁NO

There total 3 articles about C₂₂H₂₁NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

9-phenylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one (41175-05-7) + allyl bromide (106-95-6) → C22H21NO (1391713-31-7)

Guidance literature:

9-phenylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.08333h;

allyl bromide; In tetrahydrofuran; at -78 - 20 ℃; for 12.5h;

DOI:10.1002/chem.201200867

Reference yield:

1,2,3,9-tetrahydro-4H-carbazol-4-one (15128-52-6) → C22H21NO (1391713-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1.08 h / -78 °C

2.2: 12.5 h / -78 - 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.201200867

Reference yield:

benzyl bromide (100-39-0) → C22H21NO (1391713-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2: lithium diisopropyl amide / tetrahydrofuran / -78 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo402004f

upstream raw materials:

1,2,3,9-tetrahydro-4H-carbazol-4-one

9-phenylmethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one

allyl bromide

benzyl bromide

Downstream raw materials:

C₂₅H₂₆N₂O₂

C₂₅H₂₄N₂O

Refernces

• 1、 Jing, Peng,Yang, Zhen,Zhao, Changgui,Zheng, Huaiji,Fang, Bowen,Xie, Xingang,She, Xuegong. "Total synthesis of (±)-kopsihainanine A". . p. 6729 - 6732. Retrieved 2012/07/28.