{(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

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Chemical Name:{(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester
CAS No.:135697-37-9
Molecular Formula:C₂₉H₄₃N₅O₆
Molecular Weight:557.69
Hs Code.:

Synonyms:{(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

There total 13 articles about {(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 135697-32-4
(S)-5-tert-Butoxycarbonylamino-6-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-hexanoic acid 4-nitro-phenyl ester

: 135697-37-9
{(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: In dichloromethane; for 8h; Ambient temperature;
DOI:10.1021/jo00021a010

Reference yield:

: 128726-47-6
(+)-(S)-6-hydroxymethyl-2-piperidinone

: 135697-37-9
{(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 70.4 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 0 °C

2: 60 percent / DMAP, Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

3: 43 percent / potassium tert-butoxide / dimethylsulfoxide

4: pyridine / 8 h / Ambient temperature

5: 1 M LiOH / tetrahydrofuran; 2-methyl-propan-2-ol; ethanol; H₂O / 0.08 h

6: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide methiodide, 4-(dimethylamino)pyridine / CH₂Cl₂

7: 82 percent / CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; dmap; lithium hydroxide; potassium tert-butylate; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jo00021a010

Reference yield:

: 135697-06-2
(S)-(6-oxo-2-piperidinyl)methyl 4-methylbenzenesulfonate

: 135697-37-9
{(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-4-[(2-hydroxy-ethyl)-methyl-carbamoyl]-butyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / DMAP, Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

2: 43 percent / potassium tert-butoxide / dimethylsulfoxide

3: pyridine / 8 h / Ambient temperature

4: 1 M LiOH / tetrahydrofuran; 2-methyl-propan-2-ol; ethanol; H₂O / 0.08 h

5: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide methiodide, 4-(dimethylamino)pyridine / CH₂Cl₂

6: 82 percent / CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; potassium tert-butylate; 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jo00021a010