BOC-PHE-OBZL

Base Information

• Chemical Name: BOC-PHE-OBZL
• CAS No.: 66617-58-1
• Molecular Formula: C21H25 N O4
• Molecular Weight: 355.434
• Hs Code.: 2924299090
• Mol file: 66617-58-1.mol

Synonyms:Boc-Phe-OBzl;N-tert-Butoxycarbonyl-L-phenylalanine benzyl ester

Chemical Property of BOC-PHE-OBZL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 65℃
• Boiling Point: 500.2°Cat760mmHg
• Flash Point: 256.3°C
• PSA: 64.63000
• Density: 1.129g/cm³
• LogP: 4.25670
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

BOC-PHE-OBZ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-PHE-OBZL

There total 21 articles about BOC-PHE-OBZL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + benzyl bromide (100-39-0) → N-(tert-butoxycarbonyl)-L-phenylalanine benzyl ester (66617-58-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 0 - 20 ℃; for 24h; Further stages;

DOI:10.1002/chem.202005351

Reference yield: 100.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + dibenzyl dicarbonate (31139-36-3) → N-(tert-butoxycarbonyl)-L-phenylalanine benzyl ester (66617-58-1)

Guidance literature:

With dmap; In tetrahydrofuran; for 0.333333h;

DOI:10.1055/s-1994-25638

Reference yield: 99.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + benzyl alcohol (100-51-6,185532-71-2) → N-(tert-butoxycarbonyl)-L-phenylalanine benzyl ester (66617-58-1)

Guidance literature:

With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime; In water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/ol3022337 DOI:10.1021/ol3022337

upstream raw materials:

iodobenzene

(R)-N-(tert-butoxycarbonyl)-3-iodoalanine benzyl ester

benzyl bromide

N-t-butyloxycarbonyl-phenylalanine cesium salt

Downstream raw materials:

C₂₆H₃₃NO₆

L-Phenylalanine benzyl ester

L-phenylalanine benzyl ester hydrochloride

S-ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanethioate