(2S,4R,6R)-2-((3aR,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

Base Information

Chemical Name:(2S,4R,6R)-2-((3aR,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane
CAS No.:1202776-29-1
Molecular Formula:C₁₉H₂₅NO₅
Molecular Weight:347.411
Hs Code.:

Synonyms:(2S,4R,6R)-2-((3aR,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

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Chemical Property of (2S,4R,6R)-2-((3aR,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

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Technology Process of (2S,4R,6R)-2-((3aR,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

There total 3 articles about (2S,4R,6R)-2-((3aR,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1221678-59-6
(S,Z)-N-benzylidene-1-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)but-3-en-1-amine oxide

: 1202776-29-1
(2S,4R,6R)-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:: In toluene; at 100 ℃; for 72h; optical yield given as %de; diastereoselective reaction; Sealed vessel;
DOI:10.1016/j.tet.2012.05.126

Reference yield: 90.0%

: 1221678-59-6
(S,Z)-N-benzylidene-1-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)but-3-en-1-amine oxide

: 1202776-29-1
(2S,4R,6R)-2-((3aR,4R,6S,6aS)-6-methoxy-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:: In toluene; at 100 ℃; for 72h; stereoselective reaction; sealed tube;
DOI:10.1016/j.tetlet.2009.10.023

Reference yield:

: 1202776-27-9
C₁₉H₂₇NO₅

: 1202776-29-1
(2S,4R,6R)-2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-phenyl-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 6 h / 0 °C / Inert atmosphere

2: toluene / 72 h / 100 °C / Sealed vessel

With manganese(IV) oxide; In dichloromethane; toluene;
DOI:10.1016/j.tet.2012.05.126