(R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:(R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1613718-13-0
Molecular Formula:C₂₃H₂₅FN₄O₂
Molecular Weight:408.476
Hs Code.:

Synonyms:(R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 16 articles about (R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613720-71-0
(R)-1-methyl-9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-dihydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-2(1H)-one

: 1613718-13-0
(R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 90 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

3: Chiralcel AD-H 250 x 30mm I.D., 5 μm. / ethanol / Resolution of racemate

4: acetic acid; bromine / 1 h / 20 °C

5: triethylamine / methanol / 1.5 h / 20 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 90 °C

7: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; bromine; sodium carbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; ethanol; water; ethyl acetate; 6: |Suzuki Coupling;

Reference yield:

: 1613720-89-0
3-methyl-3-[1-((R)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl)vinyl]azetidine-1-carboxylic acid tert-butyl ester

: 1613718-13-0
(R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2: Chiralcel AD-H 250 x 30mm I.D., 5 μm. / ethanol / Resolution of racemate

3: acetic acid; bromine / 1 h / 20 °C

4: triethylamine / methanol / 1.5 h / 20 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 90 °C

6: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; bromine; sodium carbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; ethanol; water; ethyl acetate; 5: |Suzuki Coupling;

Reference yield:

: 1613722-30-7
3-methyl-3-[(R)-1-((R)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl)ethyl]azetidine-1-carboxylic acid tert-butyl ester

: 1613718-13-0
(R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; bromine / 1 h / 20 °C

2: triethylamine / methanol / 1.5 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 90 °C

4: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium carbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; water; ethyl acetate; 3: |Suzuki Coupling;