(R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Base Information

Chemical Name:(R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one
CAS No.:1632328-84-7
Molecular Formula:C₂₄H₂₇FN₄O₂
Molecular Weight:422.502
Hs Code.:

Synonyms:(R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Chemical Property of (R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

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Technology Process of (R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

There total 17 articles about (R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1613718-13-0
(R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

: 1632328-84-7
(R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: formaldehyd; (R)-7-(2-fluorophenyl)-4-methyl-6-[(R)-1-(3-methylazetidin-3-yl)ethyl]-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one; With methanol; acetic acid; at 20 ℃; for 1h;

With sodium cyanoborohydride; at 20 ℃;

Reference yield:

: 1613720-93-6
3-{(R)-1-[(R)-7-(2-fluorophenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triazaphenanthren-6-yl]ethyl}-3-methylazetidine-1-carboxylic acid tert-butyl ester

: 1632328-84-7
(R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

2.1: methanol; acetic acid / 1 h / 20 °C

2.2: 20 °C

With hydrogenchloride; methanol; acetic acid; In ethyl acetate;

Reference yield:

: 1613720-71-0
(R)-1-methyl-9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-dihydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-2(1H)-one

: 1632328-84-7
(R)-6-[(R)-1-(1,3-dimethylazetidin-3-yl)ethyl]-7-(2-fluoro-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triazaphenanthren-3-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 90 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

3.1: Chiralcel AD-H 250 x 30mm I.D., 5 μm. / ethanol / Resolution of racemate

4.1: acetic acid; bromine / 1 h / 20 °C

5.1: triethylamine / methanol / 1.5 h / 20 °C

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 90 °C

7.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

8.1: methanol; acetic acid / 1 h / 20 °C

8.2: 20 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; bromine; sodium carbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; ethanol; water; ethyl acetate; 6.1: |Suzuki Coupling;