4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester

Base Information

• Chemical Name: 4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester
• CAS No.: 112495-25-7
• Molecular Formula: C₃₅H₃₈N₂O₁₁
• Molecular Weight: 662.694

Synonyms:4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester

Chemical Property of 4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester

Chemical Property:

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Technology Process of 4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester

There total 3 articles about 4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-ethoxy-3-oxoprop-1-en-2-yl benzoate (108725-04-8) + 2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-malonic acid diethyl ester (112495-27-9) → 4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester (112495-25-7)

Guidance literature:

With sodium ethanolate; In ethanol; Ambient temperature;

DOI:10.1016/S0040-4020(01)86044-0

Reference yield:

2-oxo-propionic acid ethyl ester (617-35-6) → 4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester (112495-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / Et₃N

2: 70 percent / NaOEt / ethanol / Ambient temperature

With sodium ethanolate; triethylamine; In ethanol;

DOI:10.1016/S0040-4020(01)86044-0

Reference yield:

benzoyl chloride (98-88-4) → 4-Benzoyloxy-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-2-ethoxycarbonyl-pentanedioic acid diethyl ester (112495-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / Et₃N

2: 70 percent / NaOEt / ethanol / Ambient temperature

With sodium ethanolate; triethylamine; In ethanol;

DOI:10.1016/S0040-4020(01)86044-0

upstream raw materials:

3-ethoxy-3-oxoprop-1-en-2-yl benzoate

2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-malonic acid diethyl ester

2-oxo-propionic acid ethyl ester

benzoyl chloride

Downstream raw materials:

4-Benzoyloxy-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2-ethoxycarbonyl-pentanedioic acid diethyl ester

N-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-4-hydroxy-glutamic acid

4-Benzoyloxy-2-ethoxycarbonyl-2-(4-methylamino-benzoylamino)-pentanedioic acid diethyl ester

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